UK stocks drifted lower during the morning session on Monday, despite positive Covid-19 vaccine news over the weekend from AstraZeneca (AZN) and Pfizer.
At midday the benchmark FTSE 100 index was down 0.21%, at 6,027.
Pfizer chief executive Albert Bourla said on Sunday that the US company's Covid-19 vaccine could be distributed to Americans before the end of the year.
Meanwhile AstraZeneca announced it had resumed UK clinical trials of its Covid-19 vaccine following a brief pause caused by a participant experiencing an adverse reaction. The shares dipped 0.7% to £83.7.
Brake technology group Surface Transforms (SCE) soared 91% to 46.8p on news that it had won a large contract with a global vehicle manufacturer.
Surface Transforms also upgraded its annual revenue guidance and said it would increase its headcount to handle the new work.
Shares in security group G4S (GFS) surged 24% to 180p after receiving all cash offer of 190p by the world’s largest privately-owned security services company, GardaWorld.
Music and audio products group Focusrite (TUNE:AIM) rallied 10% to 907.6p, having guided for annual earnings ahead of expectations amid a 52% jump in sales.
Investment group City of London (CLIG) firmed 6.1% to 85p after funds under management rose 2% in the year to 30 June and it raised the ordinary dividend for the year to 30p compared with 27p previously.
Payments group PCI-PAL (PCIP:AIM) gained 3.0% to 41.2p, having posted a full-year loss after a rise in sales was offset by investment in its growth plans.
Investment company HgCapital Trust (HGT) added 2.2% to 281p as it posted a positive first-half performance and lifted its dividend.
HgCapital Trust declared an interim dividend of 2.0p per share, up from 1.8p on-year.
Specialist recruitment company SThree (STEM) climbed 1.6% to 250p, despite net fee revenue slumping 14% in the third quarter owing to the Covid-19 crisis.
The firm said there had been an improving underlying sequential performance since the half-year and it had brought some staff off furlough.
Telecom group Vodafone (VOD) shed 1% to 109p after it announced that due diligence had been 'substantively completed' regarding the potential sale of its 55% stake in Vodafone Egypt to Saudi Telecom.
RNA-focused therapy developer Silence Therapeutics (SLN:AIM) dropped 2% to 459p after posting a deeper first-half loss on higher R&D spending and appointing Mark Rothera as its new chief executive.
Rothera was previously CEO of Orchard Therapeutics and had also served as chief commercial officer of PTC Therapeutics.
Pub chain JD Wetherspoon (JDW) dropped 3.2% to 896p on reporting that its sales over the weekend were 22.5% below the equivalent Saturday last year.
Wetherspoon chairman Tim Martin also critisised the press for what he claimed were 'negative views' about the risk pubs pose to the spread of Covid-19.
Vaccine delivery system developer N4 Pharma (N4P:AIM) plunged 35% to 6.2p as it revealed disappointing study results for a potential Covid-19 treatment.
