LEI: 549300Q7EXQQH6KF7Z84

20 December 2024

RTW Biotech Opportunities Ltd

New Investment in Series A of Ottimo Pharma

RTW Biotech Opportunities Ltd (the "Company"), a London Stock Exchange-listed investment company focused on identifying transformative assets with high growth potential across the life sciences sector, is pleased to note a new portfolio company investment in Ottimo Pharma ("Ottimo"), a company pioneering bifunctional medicines to extend the lives of people living with cancer. Ottimo announced the completion of its Series A financing round of over $140 million. The financing will accelerate the lead asset, Jankistomig, a first-in-class PD1/VEGFR2 bifunctional antibody for multiple solid tumour indications, and a pipeline of follow-on bifunctional assets. The Company participated in the Series A alongside other investment vehicles managed by RTW Investments, LP (the "Investment Manager").

Ottimo Pharma is a private biotechnology company focused on the development of pioneering innovative cancer therapies for solid tumours. Jankistomig is designed as a dual pathway, biparatopic single-agent IgG therapy, targeting both immune checkpoint inhibition and angiogenesis in the treatment of cancer. By advancing this dual-pathway approach, Ottimo aims to offer a wider therapeutic window, improve cancer treatment outcomes and reduce the overall healthcare burden.

Roderick Wong, Managing Partner and CIO at the Investment Manager said, "We are thrilled to support Ottimo Pharma at this pivotal juncture. The innovative approach and promising potential of Jankistomig align with our mission to invest in transformative healthcare solutions. We believe Ottimo's bifunctional antibody approach holds significant promise for addressing unmet needs in oncology, and we look forward to contributing to their continued success."

The full text of the announcement can be accessed at https://ottimopharma.com.

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About Biotech Opportunities Ltd:

RTW Biotech Opportunities Ltd (LSE: RTW) is an investment fund focused on identifying transformative assets with high growth potential across the biopharmaceutical and medical technology sectors. Driven by a long-term approach to support innovative businesses, RTW Biotech Opportunities Ltd invests in companies developing next-generation therapies and technologies that can significantly improve patients' lives. RTW Biotech Opportunities Ltd is managed by RTW Investments, LP, a leading healthcare-focused entrepreneurial investment firm with deep scientific expertise and a strong track record of supporting companies developing life-changing therapies.

Visit the website at www.rtwfunds.com/rtw-biotech-opportunities-ltd for more information.

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The information in this announcement may include forward-looking statements, which are based on the current expectations and projections about future events, and in certain cases can be identified by the use of terms such as "may", "will", "should", "expect", "anticipate", "project", "estimate", "intend", "continue", "target", "believe" (or the negatives thereon) or other variations thereon or comparable terminology. These forward-looking statements, as well as those included in any related materials, are subject to risks, uncertainties and assumptions about the Company and/or its underlying investments, including, among other things, the development of the applicable entity's business, trends in its operating industry, expected use of financing proceeds and future capital expenditures and acquisitions. In light of these risks, uncertainties and assumptions, the events in the forward-looking statements may not occur.

The information contained in this announcement is given at the date of its publication (unless otherwise marked). No reliance may be placed for any purpose whatsoever on the information or opinions contained in this announcement or on its completeness, accuracy or fairness.

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