hVIVO plc

("hVIVO" or the "Company")

Exercise of Warrants

hVIVO plc (AIM & Euronext: HVO) has received notice of exercise of warrants by a former nomad and corporate finance advisor (awarded as part of the IPO of the Company in June 2019), over 1,607,142 ordinary shares of 0.1 pence each in the capital of the Company ("Ordinary Shares") at a price of 5.6 pence per share. The gross proceeds of this exercise received by the Company amount to £90,000.

The total remaining outstanding warrants over Ordinary Shares are as follows:

The Company has made application for 1,607,142 new Ordinary Shares, to be issued and allotted as a result of the warrant exercise set out above, to be admitted to trading on AIM and Euronext Growth. Admission is expected to occur at 8.00 a.m. on 6 September 2023.

Total Voting Rights

Following the admission of the 1,607,142 new Ordinary Shares, the Company's total issued ordinary share capital will consist of 680,371,877 Ordinary Shares. This figure may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the Financial Conduct Authority's Disclosure Guidance and Transparency Rules.

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Notes to Editors

About hVIVO

hVIVO plc (ticker: HVO) (formerly Open Orphan plc) is a rapidly growing specialist contract research organisation (CRO) and the world leader in testing infectious and respiratory disease vaccines and therapeutics using human challenge clinical trials. The Group provides end-to-end early clinical development services to its large, established and growing repeat client base, which includes four of the top 10 largest global biopharma companies.

The Group's fast-growing services business includes a unique portfolio of 11 human challenge models, with a number of new models under development, to test a broad range of infectious and respiratory disease products. The Company has world class challenge agent manufacturing, specialist drug development and clinical consultancy services via its Venn Life Sciences brand, and a lab offering via its hLAB brand, which includes virology, immunology biomarker and molecular testing. The Group offers additional clinical field trial services such as patient recruitment and clinical trial site services.

hVIVO runs challenge studies in London from its Whitechapel quarantine clinic, its state-of-the-art QMB clinic with its highly specialised on-site virology and immunology laboratory, and its clinic in Plumbers Row. To recruit volunteers / patients for its studies, the Company leverages its unique clinical trial recruitment capability via its FluCamp volunteer screening facilities in London and Manchester.